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Symptoms & causes Diagnosis Treatment & outlook
Eye cancer melanoma symptoms causes
Eye Cancer · Overview

Symptoms and Causes

? 5 min readReviewed: March 2024
Key Points
  • Around 850 cases of eye cancer are diagnosed in the UK each year
  • There are several types, including eye melanoma, squamous cell carcinoma, lymphoma, and retinoblastoma (a childhood cancer)
  • Eye melanoma, one of the most common types, is the focus of this article
  • It doesn't always cause obvious symptoms, and may be found during a routine eye test
  • See a doctor promptly if you notice any unusual eye symptoms

About Eye Cancer

Around 850 cases of eye cancer are diagnosed in the UK each year. Several different types can affect the eyes, including eye melanoma, squamous cell carcinoma, lymphoma, and retinoblastoma (a childhood cancer). Cancer can also occasionally develop in the tissues around the eyeball, or spread there from elsewhere in the body, such as the lungs or breasts. This article focuses on eye melanoma, one of the more common types — further information on other types of eye cancer is available through Cancer Research UK.

Symptoms

Eye cancer doesn't always cause obvious symptoms, and may only be found during a routine eye test. Possible symptoms include shadows, flashes of light, or wiggly lines in your vision, blurred vision, a dark patch in the eye that's growing, partial or total vision loss, one eye bulging, a growing lump on the eyelid or in the eye, persistent eye irritation, or, rarely, pain in or around the eye. These symptoms are often caused by more minor eye conditions rather than cancer, but it's important to get them checked by a doctor as soon as possible.

About Eye Melanoma

Melanoma is cancer that develops from pigment-producing cells called melanocytes. While most melanomas develop in the skin, they can also occur in the eye — most commonly affecting the eyeball itself (sometimes called uveal or choroidal melanoma, depending on the exact area), though it can also affect the conjunctiva or eyelid.

What Causes Eye Melanoma

Eye melanoma happens when pigment-producing cells in the eye divide and multiply too quickly, forming a tumour. It's not fully understood why this happens, but risk may be higher with lighter eye colours (blue, grey or green), white or pale skin, unusual moles, sunbed use, or overexposure to sunlight. Risk also increases with age, and most cases are diagnosed in people in their 50s.

Page last reviewed: 6 March 2024  ·  Next review due: 6 March 2027
Eye melanoma diagnosis specialist tests
Eye Cancer · Diagnosis

How Eye Melanoma is Diagnosed

? 4 min readReviewed: March 2024

Getting Referred

If a GP or optician suspects a serious eye problem, they'll refer you to a specialist eye doctor (ophthalmologist), and if melanoma is suspected, on to one of four specialist eye cancer centres in the UK, located in London, Sheffield, Liverpool and Glasgow.

Tests You May Have

At the specialist centre, you're likely to have a detailed eye examination to check for abnormalities, an ultrasound scan (using a small probe over the closed eye to assess the tumour's position and size), and a fluorescein angiogram, where photographs are taken after a dye is injected into the bloodstream to highlight the tumour. Occasionally, a fine needle may be used to take a small tissue sample (biopsy), with the genetic information analysed to help understand the chances of the cancer spreading or returning.

Page last reviewed: 6 March 2024  ·  Next review due: 6 March 2027
Eye melanoma treatment outlook survival
Eye Cancer · Treatment & Outlook

Treatment and Outlook

? 5 min readReviewed: March 2024

Treatment Options

Treatment for eye melanoma depends on the tumour's size and location, and your care team will explain the options, benefits and possible complications in detail, aiming to conserve the affected eye wherever possible. Options include brachytherapy (small radioactive plaques placed near the tumour for up to a week), external radiotherapy (aiming radiation beams at the tumour from outside), surgery to remove the tumour or part of the eye if it's small enough and some vision remains, removal of the eye (enucleation) if the tumour is large or vision has already been lost — with an artificial eye fitted afterwards to match the other one — or immunotherapy for certain types of eye melanoma or if the cancer has spread elsewhere. Chemotherapy is rarely used for eye melanoma, though it may be more suitable for other types of eye cancer.

Outlook

The outlook for eye melanoma depends on many individual factors. Since eye cancer overall is rare, survival statistics are generally based on all types of eye cancer together — in England, around 95 out of 100 people live at least a year after diagnosis, 70 out of 100 live at least 5 years, and 60 out of 100 live at least 10 years. Cancer Research UK provides more detailed information on eye cancer survival.

Page last reviewed: 6 March 2024  ·  Next review due: 6 March 2027